【摘要】 目的探讨老年无症状性脑梗死患者血清超敏C反应蛋白(hs-CRP)及同型半胱氨酸(Hcy)与颈动脉粥样硬化的关系。方法收集2009年1月—2013年5月诸暨市人民医院神经内科收治的老年脑梗死患者120例,其中无症状性脑梗死患者62例(ACI组),有症状性脑梗死患者58例(CI组),另选择同期体检健康者50例为对照组。所有患者均行颈动脉彩色多普勒超声检查,并检测血清hs-CRP和Hcy水平。结果对照组、ACI组、CI组,血清hs-CRP、Hcy水平、IMT及粥样斑块发生率呈逐渐升高趋势,3组之间差异均有统计学意义(P<0.05)。ACI组和CI组血清hs-CRP、Hcy水平、IMT及粥样斑块发生率均明显高于对照组(P<0.05),CI组血清hs-CRP、Hcy水平、IMT及粥样斑块发生率均明显高于ACI组(P<0.05)。3组不同性质颈动脉斑块发生率比较,ACI组和CI组不稳定斑块发生率高于对照组(P<0.05)。老年ACI患者无斑块、稳定斑块、不稳定斑块,血清hs-CRP、Hcy水平呈逐渐升高趋势,3组之间差异均有统计学意义(P<0.05)。不稳定性斑块组和稳定性斑块组血清hs-CRP、Hcy水平均明显高于无斑块组(P<0.05),不稳定性斑块组血清hs-CRP、Hcy水平均明显高于稳定性斑块组(P<0.05)。结论血清hs-CRP、Hcy水平和颈动脉粥样硬化的联合检测可为老年ACI患者的早期诊断及进展预测提供重要的临床参考依据。更多还原

【Abstract】 Objective To study the relationship between atherosclerosis andthe serum level of Hcy and hs-CRP in elderly patients with asymptomatic cerebral infarction. Methods From January 2009 to May 2013,120 cases of senile cerebral infarction patients were collected,including 62 cases of asymptomatic cerebral infarction( ACI) and58 cases of symptomatic cerebral infarction( CI group); 50 cases of healthy subjects were recruited as control group. The carotid artery color Doppler ultrasound,and the serum level of hs-CRP and Hcy were measured in all individuals. Results In the control group,ACI group and CI group,the level of Hcy,hs-CRP and IMT and incidence of atheromatous plaque showed a trend of increasing,the differences among 3 groups was statistical significance( P < 0. 05). The levels of Hcy,hs-CRP and IMT and the incidence of atheromatous plaque in ACI group and CI group were significantly higher than thosein the control group( P < 0. 05). The incidence of carotid plaques in ACI and CI group were higher than those in the control group( P <0. 05). In patients with ACI that was without plaque,with stable plaques or unstable plaque,the level of Hcy andhs-CRP showed a trend of rising and difference among the three groups were statistically significant( P < 0. 05). The level of Hcy and hs-CRP in plaque stability group and stability plaques group were significantly higher than those inwithout plaque group( P < 0. 05),the level of Hcy and hs-CRP in unstable plaque group were significantly higher than that of the stability plaque group( P < 0. 05). Conclusion The detection of the level of Hcy and hs-CRP and atherosclerosis can provide an important clinical reference for early diagnosis and progress of the elderly patients with ACI.更多还原