【摘要】 目的探讨社会技能训练对康复期精神分裂症患者的认知症状的疗效。方法 94例康复期患者,按随机数字表法分成实验组(n=47)和对照组(n=47),实验组予12周的社会技能训练。于基线、12周、12个月时进行WCST、TMT-A、TMT-B、P300等认知功能评定,采用重复测定资料的方差分析2组认知功能的差别。结果训练前,2组认知功能差异无统计学意义(F=0.001~1.711,P=0.207~0.973);训练后:实验组WCST总测验次数(63.30±12.45)、正确数(30.90±3.14)、持续错误数(20.53±2.01)、随机错误数(23.00±3.29)、TMT-A(57.33±11.59)、TMT-B(171.15±23.75)、数字广度(10.54±1.54)、P300波幅(9.58±1.88)μV、潜伏期(263.95±20.75)ms的变化优于对照组[(79.41±15.88)、(27.20±2.44)、(22.70±3.65)、(29.20±4.10)、(71.02±8.72)、(242.44±31.28)、(6.15±1.49)μV、(306.00±27.82)ms],差异有统计学意义(F=4.470~6.220,P=0.023~0.049)。结论社会技能训练能有效改善康复期精神分裂症患者的认知功能。更多还原

【Abstract】 Objective To explore the effects of social skill training on cognitive function for schizophrenia patients in remission. Methods A total of ninety-four schizophrenia patients were randomly( by table of random digit) divided into intervention group( n = 47) and control group( n = 47). In intervention group,social skill training plus regular therapy were adopted. WCST,TMT-A,TMT-B and P300 were used to evaluate cognitive function at baseline,12 weeks and 12 month followed-up after treatment. ANOVA of repeated measurement data was used to analyze the data. Results Before social skills training,there was no difference in two groups in cognitive function,after 12 weeks of social skills training,in intervention group,WCST total number of tests( 63. 30 ± 12. 45),the correct numbers( 30. 90 ± 3. 14),perseverative errors( 20. 53 ± 2. 01),random errors( 23. 00 ± 3. 2),TMT-A( 57. 33 ± 11. 59),TMT-B( 171. 15 ± 23. 75),digit span test( 10. 54 ± 1. 54),the amplitude( 9. 58 ± 1. 88) μV and latency( 263. 95 ± 20. 75) ms of P300 were significantly improved than control group[( 79. 41 ± 15. 88),( 27. 20 ± 2. 44),( 22. 70 ± 3. 65),( 29. 20 ± 4. 10),( 71. 02 ± 8. 72),( 242. 44 ±31. 28),( 6. 15 ± 1. 49) μV,( 306. 00 ± 27. 82) ms],the difference was significant( F = 4. 470 to 6. 220,P = 0. 023 to0. 049). Conclusion The cognitive function of schizophrenia patients may benefit more from treatment with social skill training.更多还原