【摘要】 目的探讨尿白细胞介素-18(IL-18)对原发性肾病综合征(PNS)合并急性肾损伤(AKI)的预测意义。方法分别检测39例PNS并AKI(观察组)及PNS不合并AKI(对照组)患者尿IL-18并进行对比分析,同时分析PNS合并AKI患者尿IL-18与血肌酐的相关性。结果观察组患者TC、TG、Alb、BUN、Scr平均分别为(8.2±2.2)mmol/L、(3.7±0.9)mmol/L、(25.7±5.2)g/L、(7.7±1.6)mmol/L、(201.3±32.1)mmol/L,对照组患者分别为(7.9±2.1)mmol/L、(3.6±0.8)mmol/L、(26.5±4.9)g/L、(4.3±1.5)mmol/L、(92.2±29.7)mmol/L,2组患者TC、TG、Alb比较差异无统计学意义(P>0.05),而观察组血BUN、Cr均显著高于对照组(P<0.01);观察组患者尿IL-18水平显著高于对照组(t=25.4066,P<0.01);观察组患者尿IL-18与Scr呈显著性正相关(r=0.4623,P<0.05)。结论尿IL-18检测对于PNS并发AKI具有较好的早期诊断与预测意义,值得推广。更多还原

【Abstract】 Objective To explore the precictive value of urinary IL-18 for AKI in patients with PNS. Methods Urinary IL-18 were detected in 39 patients PNS with AKI( the observation group) and 39 PNS patients without AKI( the control group),and then the correlation between urinary IL-18 and Scr were contrasted between the two groups,and analyzed. Results TC,TG,Alb,BUN,and Scr were( 8. 2 ± 2. 2) mmol / L,( 3. 7 ± 0. 9) mmol / L,( 25. 7 ± 5. 2) g / L,( 7. 7 ± 1. 6)mmol / L,( 201. 3 ± 32. 1) mmol / L in the observation group,and( 7. 9 ± 2. 1) mmol / L,( 3. 6 ± 0. 8) mmol / L,( 26. 5 ±4. 9) g / L,( 4. 3 ± 1. 5) mmol / L,( 92. 2 ± 29. 7) mmol / L in the control group,there were no significant difference in TC,TG,and Alb between the two groups( P > 0. 05),BUN,Scr in the observation group were significantly higher than those of control group( P < 0. 01),and urinary IL-18 in the observation group was( 371. 8 ± 54. 1) μg / L,significantly higher than that( 74. 3 ± 49. 2) μg / L in the control group( P < 0. 01),IL-18 had significant positive correlation with Scr in the observation group( P < 0. 05). Conclusion Urine IL-18 detection had better early diagnosis and prediction significance for AKI in patients with PNS,it’s worthy of promotion.更多还原