【摘要】 目的探讨美托洛尔联合苯那普利治疗充血性心力衰竭(CHF)伴室性心律失常的临床效果。方法选择98例CHF伴室性心律失常为研究对象,采用随机数字表法分为分为对照组(47例)和观察组(51例)。对照组予以常规内科治疗加苯那普利,观察组在上述基础上联合美托洛尔治疗。比较两组临床治疗效果,心功能指标[心率(HR)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESDD)、左室射血分数(LVEF)、QT间期(QTc)、QT离散度(QTd)、24 h室性早搏数(24 h VPB)、24 h室性心动过速(24 h PVT)]改善情况。结果观察组总有效率、心律失常下降率明显高于对照组(98.1%vs.78.7%,49.0%vs.27.7%);HR、LVESD、LVESDD等心功能指标均明显低于对照组,LVEF明显高于对照组;QTc明显高于对照组,QTd、24 h VPB、24 h PVT明显低于对照组。结论美托洛尔联合苯那普利有利于患者心室重塑,改善心功能,降低QT离散度,减少24 h室性早搏数与24 h室性心动过速数,提高治疗效果。更多还原

【Abstract】 Objective To explore the clinical efficacy of metoprolol and benazepril in treatment of patients with congestive heart failure and ventricular arrhythmia. Methods A total of 98 patients with CHF and ventricular arrhythmia were allocated in this study,and they were randomly divided into control group( 47 cases) and observation group( 51 cases). Patients in control group were given with routine medicine treatment and benazepril,and patients in observation group were treated on the basis of treatment in control group,and they were additionally administrated with metoprolol. Then the efficacy of treatment in these two groups had been compared. Results The response rate and rate of decrease of arrhythmia in observation group were significantly higher than those of control group( 98. 1% vs. 78. 7%,49. 0% vs. 27. 7%). The HR,LVESD,LVESDD and other indexes of cardiac function in observation group were significantly lower than those of control group and LVEF was significantly higher than that of control group. In addition,QTd,24 h VPB and 24 h PVT were significantly lower than those of control group and there was no obvious adverse reaction seen in these two groups. Conclusion The application of metoprolol combined with benazepril is beneficial to patients with ventricular remodeling,it can improve the cardiac function,reduce QT dispersion,reduce the number of ventricular premature beats and speed of ventricular tachycardia in 24 hours,thus it can improve the efficacy of treatment.更多还原