【摘要】 目的探讨结直肠肿瘤与幽门螺旋杆菌(Hp)感染的关系。方法回顾性分析2012年1月至2013年12月的80例结直肠肿瘤患者的临床资料。按病理结果分为结直肠腺瘤组(n=58)和结直肠癌组(n=22);另收集80例健康体检者的资料作为对照组。比较各组Hp感染情况的差异及Hp感染在结直肠肿瘤组中与年龄、性别的关系。另将结直肠腺瘤组按腺瘤部位、数目、最大径、蒂部分型和病理分型分亚组,比较各亚组间Hp感染情况。结果结直肠腺瘤组Hp感染阳率为70.7%(41/58);结直肠癌组Hp感染阳性率为72.7%(16/22);健康对照组Hp感染阳性率为45.0%(36/80)。结直肠腺瘤组、结直肠癌组Hp感染阳性率均高于对照组,差异均有统计学意义(χ2=8.997、5.308,P均<0.05)。Hp感染在不同年龄、性别结直肠肿瘤患者中差异均无统计学意义(P均>0.05)。Hp感染在不同部位、最大径、数目、蒂部分型、病理分型的结直肠腺瘤患者中,阳性率差异均无统计学意义(P均>0.05)。结论 Hp感染可能与结直肠肿瘤的发生发展存在密切关系,但在不同性别、年龄的结直肠肿瘤患者中,Hp感染无明显差异,另外,Hp感染与结直肠腺瘤的大小、部位等参数无明显相关。更多还原

【Abstract】 Objective To study the relationship between the infection of Helicobacter pylori( Hp) and colorectal neoplasma. Methods From January 2012 to December 2013,the clinical data of 80 patients with colorectal neoplasma were analyzed retrospectively. According to the pathological type of tumor,the patients were divided into the colorectal adenoma group( n = 58) and the colorectal carcinoma group( n = 22). A total of 80 healthy individuals were also enrolled as control. The differences of Hp infection were compared among the three groups. The distribution of Hp infection in different age and gender were analyzed in colorectal the colorectal adenoma group and the colorectal carcinoma group. According to the location,maximum diameter,number,type of pedicle and pathological type of adenoma,the colorectal adenoma group was divided into subgroups and the state of Hp infection was compared among the subgroups. Results The positive rates of Hp infection of colorectal adenoma group,colorectal carcinoma group and healthy control group were 70. 7%( 41 /58),72. 7 %( 16 /22) and 53. 4%( 36 /80),respectively,where the former two groups were both higher than that of the healthy control group,and the differences were statistically significant( χ2= 8. 997,5. 308,all P < 0. 05). Regarding the Hp infection,there was no difference in age and gender among 80 patients with colorectal tumor( all P >0. 05). Among 58 patients with colorectal adenoma,there was no statistical difference in the positive rate of Hp infection in different location,maximum diameter,number,type of pedicle and pathological type of adenoma( all P > 0. 05). Conclusion Hp might be involved in the development of colorectal tumor. In sex,colorectal cancer patients in age,Hp infection was no significant difference,in addition,Hp infection and colorectal adenoma size,location and other parameters no significant correlation.更多还原