【摘要】 目的评价加巴喷汀和卡马西平治疗新诊断的老年癫的有效性和保留率。方法将47例新诊断的老年癫患者随机分为加巴喷汀组和卡马西平组,分别予以加巴喷汀或卡马西平治疗,观察并比较2组发作控制情况和药物的保留率差异。结果治疗48周加巴喷汀组药物保留率为79.2%,卡马西平组为47.8%,差异有统计学意义(P<0.05)。加巴喷汀组总有效率为75.0%,卡马西平组总有效率为69.6%,2组比较,差异无统计学意义。结论加巴喷汀治疗老年癫与卡马西平疗效相当,48周的药物保留率显著高于卡马西平,提示加巴喷汀可作为治疗老年癫的一线药物。更多还原

【Abstract】 Objective To observe the efficacy and retention rate of gabapentin and carbamazepine in elderly patients with newly-diagnosed epilepsy. Methods Forty-seven elderly patients with newly-diagnosed epilepsy were randomized to receive either gabapentin( 24 cases) or carbamazepine( 23 cases). Seizure control and drug retention rate were used to evaluate the curative effect. Results Retention rate followed by a 48-week treatment period in the gabapentin group was79. 2%,compared with 47. 8% in the carbamazepine group. The difference was statistically significant( P < 0. 05). There was no significant difference in the seizure control between the gabapentin group( 75. 0%) and the carbamazepine group( 69. 6%). Conclusions Gabapentin and carbamazepine have similar effects in elderly patients with newly-diagnosed epilepsy. However,gabapentin is superior to carbamazepine in the retention rate,which could be recommended as a firstline drug in these patients.更多还原