【摘要】 目的 :探讨哮喘患儿的血清LPC和Apo B水平及其临床意义。方法 :选取我院收治的36例哮喘患儿为观察组,同期42例健康患儿为对照组,比较两组血清LPC和Apo B水平。结果 :观察组不同时期Apo B水平比较差异具有统计学意义(P<0.05);观察组急性发作期Apo B水平明显高于对照组(P<0.05);观察组LPC 18∶2和LPC20∶5水平均明显高于对照组(P<0.05);观察组急性发作期LPC 20∶5水平明显高于缓解期(P<0.05)。结论 :LPC及Apo B是哮喘患儿发病过程中的重要调节因子,在发病机制中均有重要作用。更多还原

【Abstract】 Objective: To investigate the changes of serum lysophosphatidylcholine(LPC) and apolipoprotein B(Apo B) in children with asthma and their clinical significance. Methods: Thirty-six cases of children with asthma in our hospital were selected as an observation group and 42 cases of healthy children in the same period as a control group. The levels of serum LPC and Apo B were compared between two groups. Results: The comparison of Apo B levels in different periods in the observation group showed statistical significance(P<0.05). The Apo B level in acute exacerbation period and the LPC 18:2 and LPC 20:5 level were significantly higher in the observation group than in the control group(P<0.05). The LPC 20:5 level in the observation group was significantly higher in acute exacerbation period than in the remission period(P<0.05). Conclusion: LPC and Apo B levels are the important regulators in the pathogenesis of asthma, which play important roles in the pathogenesis.更多还原