【摘要】 目的 探讨磁共振单体素MRS技术结合LC-Mod el绝对定量慢乙肝后代谢物在预测慢乙肝转归的可行性。方法 对11例健康志愿者和17例慢乙肝稳定及15例慢乙肝进展的患者行常规MRI和MRS检查,利用LC-Model波谱软件分别对代谢物Cho、Lip及Cho/Lip定量测量并进行比较。结果 Cho(a.u.)分别为7.58±5.05,11.26±7.21,17.67±11.72 3组之间有统计学意义;Lip(a.u.)分别为625.32±694.12,329.28±412.57,422.65±471.45,慢乙肝稳定组与进展组之间无明显统计学意义,与对照组有统计学意义;Cho/Lip的比值在慢乙肝稳定组与进展组无意义,与对照组比较有统计学意义。结论 单体素MRS结合LC-Mod el技术能够分析慢乙肝后病理改变的代谢物的变化;在预测慢乙肝后进展方面有一定的意义。更多还原

【Abstract】 Objective To explore magnetic resonance single voxel magnetic resonance spectroscopy(MRS) technology combined LC-Model to the absolute quantification of the metabolites in liver cirrhosis after chronic B hepatitisand,and to predict the probability of prognosis.Methods 11 healthy volunteers,17 patients stable after chronic B hepatitis(stable group),and 15 patients progress after chronic B hepatitis(progress group) underwent routine MRI and MRS scanning,and LC-Model spectrum software was used to quantificate Cho,Lip and Cho/Lip in three groups.Results Cho(a.u.) values were 7.58±5.05,11.26±7.21,17.67±11.72 respectively.There were significant differences on Cho values in three groups.Lip(a.u.) values were 625.32±694.12,329.28±412.57,422.65±471.45 respectively.There was no difference between stable group and progress group,but differences existed between stable group or progress group and control group.Cho/Lip value was no difference between stable group and progress group,but existed between stable group or progress group and control group.Conclusion Single voxel MRS technique combined LC-Model can analyze changes in metabolites after chronic B hepatitis.MRS has some predictions in liver cirrhosis after chronic B hepatitis transform to progress.更多还原