【摘要】 目的 探讨3T-MRI眶内结构定量测量在Graves眼病(GO)诊断和分期中的价值。方法 对23例GO患者与18例健康受试者行3.0T MR扫描,分别测量眼球突出度、眼球内侧脂肪厚度、冠状位各眼外肌最大截面积以及眼外肌最高信号强度与同侧颞肌的信号强度比,比较各定量参数的组间差异。对病例组各定量参数与临床活动性评分(CAS)进行相关分析,并采用受试者工作特征曲线(ROC)法计算出相关性最高的定量参数及其在判断GO活动性上的诊断价值。结果 病例组各定量参数值均明显大于对照组,差异有统计学意义(P<0.05)。眼外肌/颞肌信号强度比与CAS评分间相关性最高(r=0.730,P<0.001)。活动期与非活动期患者眼外肌/颞肌信号强度比差异有统计学意义(P=0.002),以眼外肌/颞肌信号强度比≥3.25判断GO处于活动期的诊断效能最优(敏感度81.8%;特异度83.3%)。结论 3T-MRI眶内结构定量测量可辅助指导GO的临床诊断及分期。更多还原

【Abstract】 Objective To evaluate the diagnostic and staging value of orbital structures quantitative measurement with 3T magnetic resonance imaging in patients with Graves ’ ophthalmopathy(GO).Methods Twenty-three GO patients(patient group) and eighteen healthy volunteers(contrast group) were enrolled.Quantitative measurement of orbital structures including exophthalmos values,fatty tissue thickness of the inner side of eye balls,cross-sectional areas of extraocular muscles and signal intensity ratios of extraocular muscles to the ipsilateral temporal muscles(SIR values),and they were compared between two groups.Correlations between the quantitative values and clinical active score(CAS) were accessed.Receiver operating characteristic(ROC) analysis was performed to evaluate the most relevant quantitative parameter and its diagnostic value in discriminating active from inactive GO patients.Results There were significant differences between the GO group and contrast group regarding to all the quantitative parameters(P<0.05).Strong correlation was found between SIR values and CAS(r=0.730,P<0.001).Significant difference of SIR was found between patients with active GO and inactive GO(P=0.002),and a cut off value of 3.25 might be the critical threshold value,with diagnostic sensitivity of 81.8% and specificity of 83.3% respectively.Conclusion Quantitative measurement of orbital structures with 3T MR imaging could provide assistant in diagnosing and staging of GO.更多还原