【摘要】 目的 探讨CT灌注所得“标准”肾血流量（BF）替代放射性核素法（radionuclide labeled microspheres）的有效肾血浆流量（ERPF）评估肾细胞癌患者健侧肾脏BF的可行性。方法 对26例肾癌患者行CT灌注扫描，获取健侧肾脏所选层面肾实质的平均单位BF值，应用肾实质期图像健侧肾脏肾门水平肾实质最大截面积与肾脏上下极之间最大径乘积作为肾脏“标准”体积，其与平均单位BF值的乘积作为全肾BF值的近似值，即“标准”肾BF值。应用放射性核素法获取相应健侧肾脏ERPF值。应用SPSS19.0的Pearson相关分析检验肾癌患者健肾CT灌注“标准”肾BF值与放射性核素法ERPF值的相关性。结果 26例肾癌患者行健肾CT灌注组的“标准”肾BF值为（620.59～820.76） mL·min^-1·g^-1·cm³,平均（718.87±58.40） mL·min^-1·g^-1·cm³,放射性核素法ERPF组的平均值为（244～411）mL/min,平均（320.54±55.71）mL/min。2组数据间存在正相关（r=0.754,P<0.01）。结论 肾脏CT灌注检查在一定程度上可以代替放射性核素法的肾功能检查。更多还原

【Abstract】 Objective To analyze the correlation between renal blood flow（BF） of CT perfusion and effective renal plasma flow（ERPF） of radionuclide labeled microspheres.Methods CT perfusion was applied to 26 cases of renal cell carcinoma（RCC） in order to obtain the average unit BF of the target layer of the uninjured lateral kidney. For the renal image of the uninjured lateral kidney in the nephrographic phase（NP）, we used the value of maximal renal cross-sectional area times the value of renal maximal height as the standardized volume. The product of this standardized volume and average unit BF could be used as an approximation of total renal blood flow, which was a standardized renal BF value. Meanwhile, we took radionuclide labeled microspheres into practice to obtain an ERPF value of the corresponding uninjured lateral kidney. The correlation between standard renal BF and ERPF was obtained by using Pearson chi-square test.Results The standard renal BF values of the uninjured lateral kidney for the group of 26 cases of RCC ranged from 620.59 to 820.76 mL·min^-1·g^-1·cm³(mean=718.87±58.40 mL·min^-1·g^-1·cm³), and the values of ERPF tested by radionuclide labeled microspheres ranged from 244 to 411 mL/min（mean=320.54±55.71 mL/min）. The two groups were positively correlated（r=0.754,P<0.01）.Conclusion CT perfusion imaging of the kidney, to some extent, has the potential to replace renal functional examination of radionuclide labeled microspheres.更多还原