【摘要】 目的 探讨直肠腺癌MRI表观扩散系数（ADC）值与组织病理学分级相关性。方法 测量46例经手术病理证实直肠腺癌的ADC值，与组织病理学分级比较。结果 46例直肠腺癌中，高分化14例，中分化20例，低分化12例。高分化腺癌ADC值为（1.125±0.103）×10^-3mm²/s,中分化腺癌为（1.030±0.098）×10^-3mm²/s,低分化腺癌为（0.922±0.091）×10^-3mm²/s。Kruskal-Wallis H检验显示直肠腺癌ADC值差异有统计学意义（χ²=17.351,P=0.000）。Mann-Whitney U检验显示3组间ADC值两两比较差异有统计学意义。结论 直肠腺癌ADC值可以作为判断肿瘤分级的生物学标志，为临床治疗和预后判断提供指导。更多还原

【Abstract】 Objective To investigate the relationship between apparent diffusion coefficient（ADC） value of rectal adenocarcinoma on DWI and its pathological grading. Methods The ADC values of 46 rectal adenocarcinomas were measured and compared with their histopathological grades. Results The 46 rectal adenocarcinomas included well differentiated adenocarcinomas in 14, moderately differentiated ones in 20, and poorly differentiated ones in 12. The ADC values of well, moderately and poorly differentiated adenocarcinomas were（1.125±0.103）×10^-3 mm²/s,（1.030±0.098）×10^-3 mm²/s and（0.922±0.091）×10^-3 mm²/s, respectively, exhibiting a statistical difference（χ²=17.351, P=0.000）. Mann-Whitney U test showed that difference in ADC value between different histopathological grades was statistically significant. Conclusion ADC value of rectal adenocarcinoma can be used as a biomarker for cell grading to guide treatment decision and prognosis assessment.更多还原