【摘要】 目的 探讨宫颈癌(ⅡB～ⅢB期)动脉灌注化疗栓塞(介入治疗)的临床疗效。方法 134例经病理确诊的(ⅡB～ⅢB期)宫颈癌经导管肿瘤供血动脉灌注化疗，明胶海绵颗粒栓塞子宫动脉。介入治疗2～3周行MRI及妇科检查评估肿瘤缓解情况，若降期有手术机会者，立即行广泛子宫切除+盆腔淋巴结清扫术。比较介入治疗前后肿瘤组织病理变化情况。结果 近期有效率80.6%,CR 6.0%,PR 74.6%。104例经介入治疗后切除肿瘤，手术切除率77.6%。术中见子宫颈肿瘤色泽发白、癌灶萎缩坏死。术后肿瘤组织病理示间质淋巴细胞浸润，肿瘤细胞退变。结论 动脉灌注化疗栓塞可提高ⅡB～ⅢB期宫颈癌的手术切除率。更多还原

【Abstract】 Objective To investigate clinic therapeutic effect of arterial infusion chemoembolization(AIC) in advanced cervical carcinoma(Ⅱ B-Ⅲ B).Methods A total of 134 patients with advanced cervical cancer were treated with arterial infusion chemotherapy and gelatin sponge particles was applied for uterine artery embolization in our department. Patients with advanced cervical cancer were treated by AIC for 2 to 3 weeks after MRI and gynecological examinations were applied to assess tumor response situation. If the cervical tumor were reduced too small who would be accepted radical hysterectomy and pelvic lymphadenectomy. Pathologic findings were evaluated.Results 6.0% showed a complete response, 74.6% had a partial response to AIC, making an overall response rate of 80.6%. Radical hysterectomy and pelvic lymphadenectomy in 104 patients were permitted after AIC. The tumor’s cell would be variety degenerative and necrotic after AIC. Between tumor tissue after surgery pathology showed interstitial lymphocytic infiltration.Conclusion Arterial infusion chemoembolization is improved the resectable rate in patients with stage Ⅱ B-Ⅲ B cervical cancer.更多还原