【摘要】 目的:观察晚期肺癌不同中医证型化疗后骨髓抑制的规律性。方法:对145例ⅢB或Ⅳ期初治肺癌患者进行辨证分型,并接受标准含铂双药方案化疗,观察化疗后白细胞和中性粒细胞、血红蛋白、血小板下降的最低值,比较不同证型患者出现骨髓抑制的比例和骨髓抑制的类型。结果:化疗后气虚痰湿证出现骨髓抑制比率为32.6%,阴虚热毒证为44%,气阴两虚证为43.6%,气血瘀滞证为57.1%。气虚痰湿证与阴虚热毒、气阴两虚两证差异显著,与气血瘀滞证比较有显著性差异。阴虚热毒证和气阴两虚证差异显著。阴虚热毒证、气阴两虚证和气血瘀滞证比较,差异均有统计学意义。骨髓抑制类型方面,气虚痰湿证和气血瘀滞证均以白细胞减少为主,而阴虚热毒证和气阴两虚证以血红蛋白下降为主,其中,气血瘀滞证出现血小板减少几率明显高于其他三个证型。结论:晚期肺癌证型与化疗后骨髓抑制存在一定相关性,气血瘀滞证化疗后骨髓抑制发生率最高,阴虚热毒证和气阴两虚证次之,气虚痰湿证发生率最低。更多还原

【Abstract】 Objective:To observe the correlation of TCM symdrom and myelosuppression after chemotherapy in advanced NSCLC.Methods:A total of 145 naive patients with advanced NSCLC were accepeted TCM syndrome differentiation and the first line platinum-based chemotherapy.The four groups of different TCM syndrome were compared the rate and type of myelosuppression after chemotherapy.Results:The incidence of myelosuppression in group with phlegmdampness due to deficiency of qi syndrome was 32.6%,significant difference between group with yin-deficiency and toxicstasis syndrome(44%)and group with deficiency of both qi and yin syndrome(43.6%),dramatic significant difference between group with qi stagnation and blood stasis syndrome(57.1%).Leukopenia was primary in group with phlegmdampness due to deficiency of qi syndrome and group with qi stagnation and blood stasis syndrome,while anemia was primary in group with yin-deficiency and toxic-stasis syndrome and group with deficiency of both qi and yin syndrome.Conclusion:The TCM symdrom was related to myelosuppression after chemotherapy in advanced NSCLC.Group with qi stagnation and blood stasis syndrome had more myelosuppression than other TCM syndrome groups.更多还原