Objective: To study the action of paclitaxel nanoparticle( TAX-NLC) on KB cells. Methods: F-actin and apoptosis of KB cells after being exposed to TAX-NLC were observed by laser confocal microscopy. Cytomorphology of KB cells after being exposed to TAX-NLC was observed by light microscope. Results: After KB cells were exposed to TAX-NLC,F-actin of KB cells was gathered into a mass,punctate,the microfilament function was inhibited. The apoptosis of KB cells were induced by TAX-NLC. Many multinucleated cells ...