Objective: Detected the expression of Ataxin-3,nm23 and Kiss-1,investigated the relationship between them and the clinical significance. Methods: To select 104 cases of gastric carcinoma patients with postoperative archive wax block and clinical datas from our hospital as observation group,70 cases of normal gastric mucosa were chosen as control group. Immunohistochemical methods was used to detect expression of Ataxin-3,nm23 and Kiss-1. Results: Observation group's Ataxin-3,nm23 and Kiss-1 were significant...
【更新日期】
2015-06-11
【分类号】
R735.2
【正文快照】
Modern Oncology 2015,23(12):1694-1697胃腺癌临床常见,病变进展中常出现多种蛋白表达的异常,尤其是转移相关基因的活化和抑制转移相关基因表达的丢失,使肿瘤呈进展期。Ataxin-3作为多聚谷氨酰胺蛋白,是泛素-蛋白酶体途径中重要的去泛素化酶,在全身多种组织中高表达。近些年在