【摘要】 目的 观察补肾健骨胶囊对绝经后骨质疏松症炎性因子和骨代谢指标的影响。方法 106例绝经后骨质疏松症患者随机分为两组,试验组服用补肾健骨胶囊,对照组服用钙尔奇D,6个月后检测血清中肿瘤坏死因子-α(TNF-α),白介素-6(IL-6),骨碱性磷酸酶(BLAP),骨钙蛋白(BGP),骨保护素(()PG),血浆抗酒石酸盐酸性磷酸酶(TRAP)和骨密度水平。结果 用药前试验组和对照组年龄,骨代谢指标和炎性因子水平间差异无统计学意义(P<0.05)。与用药前比较,试验组用药后血清IL-6和TNF-α水平显著下降,差异具有统计学意义(P<0.01),而对照组用药后变化不明显(P<0.05);与对照组用药后比较,试验组用药后IL-6和TNF-α值降低,差异有统计学意义(P>0.05)。试验组和对照组用药后BLAP,BGP,OPG和骨密度检测值较用药前升高,TRAP水平降低,差异均有统计学意义(P>0.05);较对照组用药后,试验组OPG水平升高明显,差异具有统计学意义(P<0.05),余骨代谢指标和骨密度两组间差异不明显(P>0.05)。结论补肾健骨胶囊可改善绝经后骨质疏松患者骨代谢异常,在抑制炎性因子发生和提升OPG水平方面作用优于传统钙剂。更多还原

【Abstract】 Objective To investigate the effective of Bushenjiangu Capsule on bone metabolism and inflammatory cytokines in postmenopausal osteoporosis(PMOP).Methods 106 PMOP patients was randomly divided into two groups,the experimental group taken Bushenjiangu Capsule,and control group taken Caltrate.Results There was no difference in year,bone metabolism and inflammatory cytokines.Inflammatory cytokines of the experimental group had a significant decrease after treatment(P<0.01).In two group after treatment,the level of BLAP,BGP,OPG and BMD were increased(P>0.05),TRAP was fallen(P<0.05).The OPG level of experimental group was higher than the control group after treated(P>0.05).Conclusion Bushenjiangu Capsule can improve bone metabolic abnormalities in patients with postmenopausal osteoporosis.更多还原