【摘要】 本文的目的是分析脾静脉血栓(SVT)对肝门静脉系统血流动力学参数的影响。根据某肝门静脉高压症患者的CT图像和商业软件MIMICS重建了其真实的肝门静脉系统模型,采用彩色多普勒超声法测出了肝门静脉系统内的血流速度,作为模拟的入口边界条件,应用计算流体力学(CFD)方法模拟了肝门静脉系统内血流动力学参数的变化并分析了对生理过程的影响。结果显示:SVT会对肝门静脉系统的血流动力学参数造成严重影响,血液流经SVT时压强降低、流速和壁面剪切力增加,血液流动的阻力增加,门静脉主干内血流速度减缓、压力梯度减小、壁面剪切力的分布更加均匀。SVT会导致对肝脏的供血能力下降,在血栓的周围和门静脉主干内形成新血栓的可能性增加。更多还原

【Abstract】 This paper aims to analyze the impact of splenic vein thrombosis(SVT)on the hemodynamic parameters in hepatic portal vein system.Based on computed tomography(CT)images of a patient with portal hypertension and commercial software MIMICS,the patient’s portal venous system model was reconstructed.Color Doppler ultrasound method was used to measure the blood flow velocity in portal vein system and then the blood flow velocities were used as the inlet boundary conditions of simulation.By using the computational fluid dynamics(CFD)method,we simulated the changes of hemodynamic parameters in portal venous system with and without splenic vein thrombosis and analyzed the influence of physiological processes.The simulation results reproduced the blood flow process in portal venous system and the results showed that the splenic vein thrombosis caused serious impacts on hemodynamics.When blood flowed through the thrombosis,blood pressure reduced,flow velocity and wall shear stress increased.Flow resistance increased,blood flow velocity slowed down,the pressure gradient and wall shear stress distribution were more uniform in portal vein.The blood supply to liver decreased.Splenic vein thrombosis led to the possibility of forming new thrombosis in portal vein and surroundings.更多还原