【摘要】 心房颤动是临床常见的心律失常,药物是心房颤动的主要治疗方法。胺碘酮和心律平等药物虽然可以治疗和转复心房颤动,但长期应用会引起恶性心律失常和心脏外的副作用。抑制Kv1.5钾通道电流,可选择性延长心房肌动作电位时程及有效不应期,改善心房肌的电重构和组织重构。近年来关于Kv1.5钾通道及其阻滞剂的研究迅速发展并引起广泛关注。为进一步探讨Kv1.5钾通道是否可能成为心房颤动的治疗靶点,我们对目前相关研究进展作一综述。更多还原

【Abstract】 Atrial fibrillation(AF) is the most common arrhythmia. Pharmacological therapy is the major treatment of AF.Presently, the available drugs like amiodarone and propafenone could make the rhythm disorder and increase the risk of ventricular arrhythmias or extracardiac toxicity when the patients take them for a long time. The inhibition of the Kv1.5 potassium ion channel can selectively prolong the atrial action potential duration(APD) and the effective refractory period(ERP) so as to improve the atrial electrical remodeling. In recent years, more and more researches about the Kv1.5 channel blockers have been explored and concerned.Thus, this paper reviewed the progress and development of Kv1.5 channel in order to investigate the mechanism and effects of Kv1.5 on the treatment of AF.更多还原