【摘要】 Micro RNAs(miRNA)是一类在转录后水平调控基因表达的小分子非编码RNAs,通过调节细胞的增殖、分化、凋亡使机体维一个动态平衡。近年来,大量研究表明许多miRNA可作为原癌基因或者抑癌基因参与肿瘤的发生、发展,进一步研究发现,通过检测和调控这些miRNA,可用于肿瘤的早期诊断和治疗。最近一系列研究发现miRNA-451(miR-451)在许多肿瘤中存在差异性表达,与这些肿瘤的发生、发展、治疗有着密切的联系。本文对人类肿瘤中miR-451表达、调控的相关研究做一综述,为miR-451在肿瘤的诊断、治疗及预后中的应用提供重要资料。更多还原

【Abstract】 Micro RNAs(miRNAs) are one kind of short non-coding RNAs that regulate gene expression at the post-transcription level, and maintain a dynamic balance of body by regulating cell proliferation, differentiation, and apoptosis. Recently, a lot of studies have revealed that some miRNAs are involved in the tumorigenesis and tumor progression as oncogenes or tumor suppressors. Further studies showed that it can be used for the early diagnosis and therapy of cancer by detecting and/or regulating these miRNAs. Lot of research indicated that the expression of miRNA-451(miR-451) is non-identical in different tumors, and it may play a critical role in tumorigenesis, tumor progression and tumor therapy. In this review, we summarize the relevant research about the expression and regulation of miR-451 in various human tumors, and try to provide important information for cancer diagnosis, treatment and prognosis.更多还原