【摘要】 目的:探讨纳米二氧化硅(Nano-Si O2)对子代雌性小鼠动情周期的影响。方法:选择8周龄的ICR孕鼠6只,随机平均分为两组,一组在E5.5~E11.5时隔天注射纳米二氧化硅,另外一组注射PBS,每组取子代雌性小鼠各3只,待其自然生长到7周龄时,每日采用巴氏染色法检查其动情周期。结果:与注射PBS的子代雌性小鼠相比,注射Nano-Si O2的子代雌性小鼠的动情周期的总时间无明显差异(P>0.05),动情前期的时间明显缩短,动情后期的时间明显延长(P<0.05),动情期虽然缩短,但差异不显著(P>0.05)。结论:孕期暴露于Nano-Si O2未导致子代雌性小鼠动情周期的紊乱,但对其生殖功能可能有一定的影响。更多还原

【Abstract】 Objective: To study the effects of nano silica(Nano-SiO2) on the estrous cycle of female mice. Methods: Six ICR pregnant rats at 8 weeks were selected and randomly divided into two groups: one group was injected with nano silica in E5.5-E11.5 every other day, while the other group was injected with PBS. Three offspring female mice were taken daily by PAP staining examination of the estrous cycle in each group when they grow up to 7 weeks were. Results: Injection of Nano- SiO2 of offspring female mice compared with injection of PBS of offspring female mice, there were no significant differences in total time of the estrous cycle of offspring female mice(P>0.05); proestrus time was significantly shorter and metestrus time was significantly prolonged(P<0.05); although the estrous period was shortened, but the difference was not significant(P>0.05). Conclusion: Prenatal exposure to Nano-SiO2 did not result in offspring female mice estrous cycle disorder, but may have a certain influence on the reproductive function.更多还原