【摘要】 微小Rn A-133(micro Rn A-133,mi R-133)是一种在骨骼肌和心肌特异表达的非编码小Rn A,其在心肌肥大等多种肌源性疾病中发挥重要作用。近年研究发现,多种肿瘤组织存在mi R-133的表达紊乱,其通过转录后抑制靶基因,如EGFR、i GF-1R、MMPs等的表达参与肿瘤细胞的增殖、凋亡、侵袭和转移等多种病理过程,并与肿瘤的发生发展密切相关。了解mi R-133的表达、调控及其在肿瘤等疾病中的作用及机制,可为其进一步的临床应用奠定基础。现就mi R-133与恶性肿瘤关系的研究进展进行综述。更多还原

【Abstract】 miR-133 is a group of muscle-specific non-coding small RNAs which is specifically expressed or highly enriched in skeletal muscle and/or myocardium. it plays a crucial role in muscle-related diseases such as cardiac hypertrophy. Recent studies showed that the disturbance of mi R-133 expression could be detected in different kinds of tumors, and was involved in proliferation, apoptosis, invasion and metastasis of various tumor cells by directly suppressing target gene such as EGFR, i GF-1R and MMPs. it is thought that the dysregulated expression of mi R-133 is closely correlated with tumorigenesis and metastasis. Understanding the expression, regulation, and the role and mechanism of mi R-133 will lay a strong foundation for clinical application. The relationship between mi R-133 and its target genes and malignant tumors will be summarized in this article.更多还原