【摘要】 全球性气候变化使植物遭受多样的极端环境胁迫更加频繁,在这种条件下植物体积累超量的活性氧(ROS)会氧化损伤细胞内多糖、DNA、脂类和蛋白质等大分子。为了维持体内的氧化还原平衡和防止环境胁迫的破坏,植物体内进化出清除超量活性氧的系统,这其中就包括Msr(methionine sulfoxide reductase)家族酶系统。蛋白质中的蛋氨酸(Met)极易被活性氧氧化为甲硫氨酸亚砜(Met SO),从而导致相应蛋白质构型和活性的改变,幸运的是这种改变可以被Msr家族逆转。根据作用底物的不同,植物体内Msr家族可以分为A和B两个亚家族。本综述首先分析了Msr的发现历史、蛋白质特性和催化机制,其次综述了植物中Msr基因家族的组成,再次对Msr基因家族的生理功能的研究进展进行总结,最后对下一步研究做一简要展望。更多还原

【Abstract】 Global climate change makes the plants expose to diverse extreme environmental stresses more frequently, which can produce excess reactive oxygen species(ROS) accumulation resulting in oxidative damages of intracellular polysaccharides, DNA, lipids and proteins and other macromolecules. In order to maintain redox balance and to protect against environmental stresses, plants have evolved a ROS-scavenging system to eliminate excess ROS, including ROS-removing systems, such as Msr(methionine sulfoxide reductase) gene family. Methionine(Met) in proteins can easily be oxidized to methionine sulfoxide(Met SO) by ROS, which leads to modification of conformation and activity for related proteins. Fortunately, this change can be reversed by Msr gene family. According to substrate stereospecificity, plant MSR family can be divided into two subfamilies, A and B. In this review, firstly, we have analyzed the research history, protein properties and catalytic mechanism of Msr family. Secondly, we have summarized the composition of plant Msr gene family. Thirdly, we have described the research progress on physiological function of Msr gene family. Finally, we make a simple prospect for the further research.更多还原