The present study was designed to investigate the inhibitory effects of intravenous general anesthetic propofol(0.1–3.0 mmol/L) on excitatory synaptic transmission in supraoptic nucleus(SON) neurons of rats, and to explore the underlying mechanisms by using intracellular recording technique and hypothalamic slice preparation. It was observed that stimulation of the dorsolateral region of SON could elicit the postsynaptic potentials(PSPs) in SON neurons. Of the 8 tested SON neurons, the PSPs of 7(88%, 7/8) n...
【基金】
supported by the Anhui Provincial Natural Science Foundation,China(No.1408085MH155);
the Natural Science Foundation of the Department of Education,Anhui Province,China(No.KJ2012B203);
the National Natural Science Foundation of China(No.31271155,31200828);
Cultivate Foundation of Wannan Medical College(No.WK2013Z03);
Scientific Research Foundation for Ph.D. of Wannan Medical College,China(No.201402)
【更新日期】
2016-01-25
【分类号】
R338
【正文快照】
Propofol is a new type of intravenous anesthetics,1 MATERIALS AND METHODSwhich is widely used for induction and maintenance ofanesthesia and intraoperative and postoperative seda-1.1 Hypothalamic slice preparationtion.Propofol has more advantages compared
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