The aim of the present study was to investigate the role of calcineurin in the down-regulation of left ventricular transmural voltage-dependent K+ currents in heart failure. Transverse aorta was banded by using microsurgical techniques to create mouse heart failure model. Sham-operated(Sham) or aorta banded(Band) mice were randomized to receive calcineurin inhibitor cyclosporine A(Cs A) or vehicle. The densities and kinetic properties of voltage-dependent K+ currents, as well as action potential(AP), of lef...
【基金】
supported by the National Natural Science Foundation of China(No.30370571);
Science and Technology Program of Hebei Province,China(No.09276102D-4);
the Research Project of Education Department,Hebei Province,China(No.ZD2014001)
【更新日期】
2015-09-21
【分类号】
R541.6
【正文快照】
The work was supported by the National Natural Science Foundation of China(No.30370571),Science and Technology Pro-gram of Hebei Province,China(No.09276102D-4)and the Research Project of Education Department,Hebei Province,China(No.ZD2014001).心肌肥厚、心
| 
推荐 
点击下列相关研究机构和相关文献作者，可以直接查到这些机构和作者被《中国知识资源总库》收录的其它文献，使您全面了解该机构和该作者的研究动态和历史。
