【摘要】 目的:考察健脾生血颗粒对大鼠缺铁性贫血的治疗效果。方法:采用给予低铁饲料的方法建立大鼠缺铁性贫血模型,将实验动物随机分为模型对照组、正常对照组、健脾生血颗粒组、健脾生血浸膏组、硫酸亚铁组,分别于给药10天、20天后测定相关血常规、血清铁水平。结果:补铁后,健脾生血颗粒组、健脾生血浸膏组、硫酸亚铁组大鼠HGB、RBC、HCT、血清铁水平均高于对照组;健脾生血颗粒组的血清铁水平明显高于健脾生血浸膏组、硫酸亚铁组(P<0.01)。结论:与对照组相比,健脾生血颗粒、健脾生血浸膏、硫酸亚铁均可改善大鼠缺铁性贫血的症状,且健脾生血颗粒的效果最佳。更多还原

【Abstract】 This study was aimed to investigate the mechanism of Jian-Pi Sheng-Xue(JPSX) granules on iron-deficiency anemia(IDA) rats. Low iron diet was given to establish IDA rat model. Rats were randomly divided into the model control group, normal control group, JPSX granules group, JPSX extract group and the ferrous sulfate group. The hematological indexes and serum ferritin were measured 10 days and 20 day after medication. The results showed that with iron supplements, the levels of hemoglobin(HGB), red blood cell(RBC), hematocrit(HCT) and serum ferritin of the JPSX granules group, JPSX extract group and the ferrous sulfate group were higher than those of the control group. The level of serum ferritin of the JPSX granules group was obviously higher than that of the JPSX extract group and the ferrous sulfate group(P < 0.01). It was concluded that compared with the control group, JPSX granules, JPSX extract and ferrous sulfate can improve symptoms of IDA in rats. And JPSX granules had the best effect.更多还原