【摘要】 目的观察滋膵蠲痹方联合经皮穴位电刺激治疗糖尿病周围神经病变(DPN)的临床疗效。方法将132例DPN患者随机分为甲钴胺组、经皮穴位电刺激组(电刺激组)、滋膵蠲痹方组(中药组)、经皮穴位电刺激+滋膵蠲痹方组(联合组),每组33例,各组给予相应治疗,疗程1个月。观察临床症状疗效、多伦多临床评分(TCSS)、血糖、踝肱指数及足背动脉流速等指标变化情况。结果 1甲钴胺组、电刺激组、中药组及联合组临床症状疗效总有效率分别为48.5%、74.2%、78.1%、90.6%,电刺激组、中药组和联合组总有效率高于甲钴胺组(P<0.01)。2治疗后各组TCSS评分均较治疗前显著降低(P<0.01);联合组、电刺激组和中药组TCSS评分明显低于甲钴胺组(P<0.05,P<0.01),且联合组TCSS评分低于电刺激组和中药组(P<0.05)。3治疗后,电刺激组、中药组和联合组血糖(FPG、2 h PG)水平显著下降(P<0.05,P<0.01),且联合组FPG、2 h PG水平明显低于甲钴胺组(P<0.01)。4治疗后,联合组、电刺激组和中药组踝肱指数和足背动脉流速较治疗前明显升高(P<0.01);且联合组、电刺激组、中药组足背动脉流速高于甲钴胺组(P<0.05,P<0.01)。结论滋膵蠲痹方联合经皮穴位电刺激治疗糖尿病周围神经病变可显著改善临床症状和外周血流动力学。更多还原

【Abstract】 Objective To observe the clinical efficacy of combined "Zicui Juanbi Decoction"and transcutaneous acupoint electro-stimulation( TAES) in the treatment of diabetic peripheral neuropathy( DPN). Methods One hundred and thirty two cases of DPN were randomized into four groups( mecobalamine group,TAES group,herbal group and combined group,33 cases in each group),and treated by respective methods for one month. The clinical efficacy,Toronto clinical system scores( TCSS),blood glucose,ankle-brachial blood pressure index( ABI) and velocity of dorsal pedal artery were observed before and after treatment.Results 1The clinical effective rate was 48. 5%,74. 2%,78. 1% and 90. 6% respectively in mecobalamine group,TAES group,herbal group and combined group,with higher rates in the latter three groups than in the former group( P < 0. 01). 2After treatment,the TCSS were significantly lowered in the TAES group,herbal group and combined group( P < 0. 01); the TCSS was lower in the TAES group,herbal group and combined group than in the mecobalamine group( P < 0. 05,P < 0. 01),and with lower TCSS in the combined group than in the TAES group and herbal group( P < 0. 05). 3After treatment,the levels of blood glucose( FPG,2h PG) were reduced in the TAES group,herbal group and combined group( P < 0. 05,P < 0. 01),with lower level in the combined group than in the mecobalamine group( P < 0. 01). 4After treatment,the velocity of dorsal pedal artery in the combined group,herbal group and combined group was increased( P < 0. 01),with higher velocity in these three groups than in the tomecobalamine group( P < 0. 05,P < 0. 01). Conclusion Combined "Zicui Juanbi Decoction"and transcutaneous acupoint electro-stimulation( TAES) is quite effective against diabetic peripheral neuropathy in relieving clinical symptoms and peripheral hemodynamics.更多还原