【摘要】 目的分析粤西地区肾功能代偿期Ig A肾病患者并发高尿酸血症的影响因素。方法回顾性分析328例肾功能代偿期Ig A肾病患者的临床资料,分析高尿酸血症的影响因素。结果纳入Ig A肾病患者高尿酸血症发生率38.4%(126/328),单因素回归分析显示,年龄、血肌酐、血尿素氮、血清甘油三酯、血清总胆固醇、肾小球球性硬化评分、肾小球损伤积分、肾小管-间质损伤评分、肾小血管损伤评分和Lee氏分级可能与肾功能代偿期Ig A肾病患者并发高尿酸血症有关(P均<0.05)。多因素Logistic回归分析显示,高甘油三酯血症、肾小血管损伤评分>2分与Ig A肾病患者并发高尿酸血症有关(P均<0.05)。结论高甘油三酯血症和肾小血管损伤评分>2分是粤西地区肾功能代偿期Ig A肾病患者并发高尿病血症的独立危险因素。更多还原

【Abstract】 Objective To analyze the risk factors for Ig A nephropathy complicated with hyperuricemia in renal function compensatory phase of patients in western part of Guangdong province. Methods The clinical and pathological data of328 patients with Ig A nephropathy were selected to analyze the risk factors of hyperuricemia. Results The incident of hyperuricemia in patients with Ig A nephropathy was 38. 4%( 126 /328). Univariate regression analysis suggested that the age,serum creatinine,blood urea nitrogen,serum triglyceride,serum total cholesterol,glomerulus sclerosis score,glomerular injury integral,tubular-interstitial injury score,renal small vessel injury score and Lee’s grade might be related to the Ig A nephropathy patients complicated with hyperuricemia( all P < 0. 05). Multivariate regression analysis showed that the serum triglyceride and renal small vessel injury score > 2 were related with the occurrence of hyperuricemia in patients with Ig A nephropathy( all P < 0. 05). Conclusion The hypertriglyceridemia and renal small vessel injury score > 2 are independent risk factors for patients with Ig A nephropathy in renal function compensatory phase from western part of Guangdong province.更多还原