【摘要】 目的探讨钙离子阻滞剂和硝酸脂类药物与胃食管反流病的关系。方法根据怀疑患有胃食管反流病(GERD)的患者(107例)所服用的药物种类不同进行分组,分别为钙离子阻滞剂组、硝酸酯类组和合用组。对患者进行胃镜检查和/或PPI试验治疗以确定GERD。结果钙离子阻滞剂组、硝酸酯类组和合用组GERD发病率分别为36.67%、27.5%、55.88%,合用组GERD的发病率明显高于其他2组,3组之间比较有统计学意义(P<0.05)。结论联合应用钙离子阻滞剂组、硝酸酯类药物增加了胃食管反流病的发病率。更多还原

【Abstract】 Objective To investigate the relationship between calcium-channel blocker,nitrate compound and the gastroesophageal reflux disease. Methods Patients( n = 107) with GERD were divided into calcium-channel blocker,nitrate compound and the combination group,according to the different groups of drugs used in patients. Patients underwent gastroscopy and / or PPI test. Results The incidence of GERD was 36. 67%,27. 5%,55. 88%,and the incidence of GERD in the combination group was significantly higher than other 2 groups( P < 0. 05). Conclusion The incidence of gastroesophageal reflux disease was increased by the combination of calcium-channel blocker,nitrate compound.更多还原