【摘要】 目的:观察针刺结合大承气汤对大鼠粘连性肠梗阻血浆SOD、NO、DAO的影响,为深入探讨针刺对粘连性肠梗阻的作用机制提供依据。方法:制备大鼠粘连性肠梗阻模型,随机分为正常组、假手术组、模型组、大承气汤组、单纯针刺组、针药组(大承气汤加用针刺)。给予相应药物或针刺治疗,治疗3天后处死大鼠取血浆,测定血浆SOD、DAO和NO含量。结果:与空白组比较,模型组血浆NO和DAO的含量增加(P<0.05,P<0.05),血浆SOD的含量降低(P<0.05);与模型组比较,治疗后血浆NO的含量药物组、针刺组和针药组明显降低(均P<0.05),治疗后血浆SOD的含量针刺组和针药组升高(P<0.05,P<0.05),治疗后血浆DAO的含量药物组、针刺组和针药组降低(P<0.05,P<0.05,P<0.05)。结论:针刺结合大承气汤治疗具有良好的治疗粘连性肠梗阻的作用。更多还原

【Abstract】 Objective: To observe the effect of acupuncture combined with Dachengqi Decoction on superoxide dismutase(OD),nitric oxide( NO) and diamine oxidase( DAO) in rats with adhesive intestinal obstruction,and provide experimental evidence for the relationship of SOD,NO and DAO changes with the adhesive intestinal obstruction of acupuncture combined with Dachengqi Decoction. Methods: The 60 SD rats model of adhesive intestinal obstruction were randomly divided into 6groups( 10 animals in each) : the normal( N) group,sham-operation( S) group,model( M) group,Dachengqi Decoction( DS)group,acupuncture( A) group,and Dachengqi soup combination acupuncture( DS-A) group. Succeed in the model. The rats were killed after three days adopt the serum. The serum NO,SOD and DAO were detected. Results: When compared with the normal group,the serum SOD was decreased( P <0. 05),NO and DAO( P <0. 05,P <0. 05). And the serum NO and DAO was increased in all experimental groups compared with the model group,the serum SOD was increased in the DS group compared with the model group( P>0. 05),and was increased in the A group and DS-A group compared with the model group( P <0. 05,P <0. 05). Conclusion: Acupuncture combined with Dachengqi Decoction is effective for intestinal obstruction.更多还原