【摘要】 NF-κB是一类核转录因子,可与其靶基因启动子区的DNA序列结合,而启动基因转录的功能。它们广泛参与胚胎发育、细胞增殖、细胞凋亡、免疫反应、炎症反应、病毒感染等过程。目前研究已经证实NF-κB信号通路在骨的发育和形成中具有重要的调控作用,NF-κB信号通路的阻断可导致骨发育异常或相关疾病的发生。NF-κB通过调控成骨细胞、破骨细胞、骨细胞和软骨细胞的增殖、分化和凋亡等生物学过程,调控骨的发育和重塑,并在骨相关疾病的发生中发挥重要的调控作用。更多还原

【Abstract】 NF-κB is a set of multifunctional transcriptional factors that regulate expression of genes involved in numerous normal cellular activities.It was confirmed that NF-κB played a critical role in embryo development,cell proliferation and apoptosis,immunological reaction,inflammation and virus infections.Currently,there are numerous studies have indicated that NF-κB has roles in bone development,endochondral ossification,osteoclast and osteoblast functions,and common bone diseases.Here we review the roles for NF-κB in bone and in common bone diseases.更多还原