【摘要】 早产儿脑白质损伤(WMD)是神经系统伤残的主要原因之一。影像学是WMD的确诊依据。目前研究认为,促红细胞生成素(EPO)可促进早产儿脑发育并对脑损伤有保护作用。EPO脑保护的主要机制是抗凋亡、抗氧化、抗炎症、抗惊厥和促进脑血管新生等。同时,EPO基因又存在多态性,可能与早产儿WMD的个体易感性差异相关联。更多还原

【Abstract】 White matter damage(WMD) of premature infants is one of the significant causes leading to neurological disabilities,and imaging is the way to identify the disease.Up to now,researches have found that erythropoietin(EPO) could not only improve brain development,but have protective effect on preterm neonatal brain injury.The fundamental mechanism of EPO is its ability of inhibiting apoptosis,anti-oxidation,anti-inflammatory,anti-epilepsy,and angiogenesis.Meanwhile,there are gene polymorphisms in EPO gene,which maybe relate with the individual susceptibility difference in WMD of premature infants.更多还原