【摘要】 目的:观察腰痛宁胶囊对腰椎骨性关节炎(LOA)的疗效及其对患者血清中基质金属蛋白酶-3(MMP-3)水平的影响。方法:采用随机、双盲、对照研究方法,将108例患者分为治疗A组(腰痛宁胶囊4粒组),治疗B组(腰痛宁胶囊6粒组)以及对照组(痹痛宁胶囊组),每组36例;连续用药4周,观察治疗前后患者血清MMP-3水平的变化及临床疗效。结果:3组治疗后改良日本整形外科学会(JOA)评分较治疗前均升高,治疗B组较治疗A组及对照组上升更显著(P<0.01);治疗后3组患者血清MMP-3水平均下降,治疗B组MMP-3下降较治疗A组及对照组更为明显(P<0.01)。结论:腰痛宁胶囊治疗LOA疗效显著,能够下调MMP-3的水平,这可能是其治疗LOA的作用机制之一。更多还原

【Abstract】 Objective: To study the therapeutic effect of Yaotongning capsules for lumbar osteoarthritis(LOA)and to observed the effect on the level of matrix metalloproteinase-3(MMP-3). Methods: One hundred and eight patients were divided into three groups,treatment group A(with 4 capsules of Yaotongning capsules),treatment group B(with 6 capsules of Yaotongning capsules) and control group(Bitongning capsules) by randomized,double-blind and controlled method. Each group had 36 patients. After treatment for 4 continuous weeks,the changes of serum level of MMP-3 were observed,and the clinical efficacy was evaluated. Results:After treatment,the scores of Japanese Orthopaedic Association(JOA)of the three groups were higher than those before treatment,and the increase in treatment group B was superior to that of the other two groups(P < 0.01). After treatment, MMP-3 level was decreased in all of the three groups,and the decrease in treatment group B was superior to that of the other two groups(P < 0.01). Conclusion: Yaotongning capsules is effective for the treatment of LOA,and one of the therapeutic mechanisms is probably related with the decrease of serum MMP-3 level.更多还原