【摘要】 目的观察分析糖尿病性心肌病(DCM)患者血清C-反应蛋白(CRP)和白细胞介素-37(IL-37)的水平,探讨CRP和IL-37与DCM发病的关系。方法对深圳市宝安区人民医院2009年9月至2013年2月收治的24例确诊DCM患者及同期的健康体检者22人进行空腹血糖、血胆固醇(TC)、血甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDL-C)、血尿素氮(BUN)、血肌酐(Cr)等生化指标检测,同时采用免疫透射比浊法测定血清CRP含量,ELISA法检测血清IL-37水平,对比分析两组血清CRP和IL-37水平与DCM患病的相关性。结果 DCM组CRP含量为(6.9±1.4)mg/dl,对照组为(1.9±0.4)mg/dl,差异有统计学意义(P<0.05);CRP含量与血清HDL-C水平呈负相关(r=-0.938,P<0.05),而与LDL-C水平呈正相关(r=0.665,P<0.05)。DCM组IL-37含量为(12.2±8.9)pg/ml,对照组为(2.8±4.5)pg/ml,差异有统计学意义(P<0.05);IL-37含量与HDL-C水平呈负相关(r=-0.765,P<0.05),而与LDL-C水平呈正相关(r=0.894,P<0.05)。结论 DCM患者血清CRP和IL-37水平明显升高,且均与HDL-C水平呈负相关,与LDL-C水平呈正相关,提示炎症与DCM的发病和发展密切相关。更多还原

【Abstract】 Objective To investigate the relationship of C-reactive protein(CRP) and interleukin-37(IL-37) with diabetic cardiomyopathy(DCM). Methods 24 patients with DCM and 22 individuals without DCM were selected from May 2011 to May 2012 for this study. Serum levels of CRP and IL-37 in all subjects were determined by immunonephelometry,immunoassay and ELISA. Results The levels of serum CRP in the patient group and control group were(6.9±1.4)mg / dl and(1.9±0.4)mg / dl,respectively,and were significantly different(P<0.05). The serum level of CRP was related negatively with high density lipoprotein cholesterol(HDL-C)(r =-0.938,P <0.05),and positively with low density lipoprotein cholesterol(LDL-C) levels(r=0.665,P<0.05). There was also significant difference for the concentrations of IL-37 between the two groups[(12.2 ±8.9)pg / ml and(2.8 ±4.5)pg / ml,respectively,P <0.05) ]. The level of IL-37 was related negatively with HDL-C(r=-0.765,P<0.05),and positively with LDL-C levels(r=0.894,P<0.05). Conclusion Serum levels of CRP and IL-37 in DCM patients were higher than those in normal individuals. CRP and IL-37 were both related negatively with HDL-C and positively with LDL-C,displaying inflammation is closely related to the pathogenesis and development of DCM.更多还原