【摘要】 目的探讨CYP2B6基因多态性与抗结核药物性肝损伤(ADIH)的关系。方法选取在2013年1月至2013年12月唐山市结核病医院确诊并接受规范抗结核治疗的结核病患者中发生肝损伤的175例结核病患者为病例组,未发生肝损伤的185例患者为对照组,对其进行流行病学调查,同时提取外周血DNA并鉴定CYP2B6-785A/G位点的基因型,最后对实验结果进行统计学分析以判断其与ADIH的关系。结果 CYP2B6-785A/G位点多态性AA、AG、GG基因型在病例组(33.1%、52.6%、14.3%)和对照组(35.7%、50.8%、13.5%)中的分布比较,差异无统计学意义(P>0.05),等位基因A、G在病例组和对照组中分别占59.4%、40.6%和61.1%、38.9%,差异无统计学意义(P>0.05)。结论CYP2B6-785A/G位点基因多态性可能与抗结核药物性肝损伤的发生无相关性。更多还原

【Abstract】 Objective To investigate the relationship between CYP2B6 genetic polymorphisms and anti- tuberculosisdrug-induced hepatic injury. Methods From January 2013 to December 2013, 360 Chinese Han patients with tuberculosisreceived the anti- tuberculosis therapy were selected as subjects, among them, 175 patients with anti- tuberculosis drug-induced hepatic injury(ADIH)were in ADIH group, while other 185 patients without hepatic-injury were selected as control.The data of the cases were epidemiologically surveyed and their genetic types were also identified. Results No significantdifferences in genotypes of CYP2B6-785A/G(AA,AG,GG)between ADIH cases and that of the control group were noticed(P>0.05); so did the distribution of A and G alleles in cases of both group(P>0.05). Conclution CYP2B6 gene-785A/Gpolymorphism may not be associated with anti-tuberculosis drug-induced liver injury in Chinese Han people.更多还原