【摘要】 目的探讨血清甲胎蛋白(AFP)、α-L岩藻糖苷酶(AFU)、糖类抗原(CA19-9)联合检测在原发性肝癌(PHC)中的诊断价值。方法 2011年6月~2012年6月住院的原发性肝癌(PHC)患者34例,另选32例肝硬化患者及同期在医院内体检的健康者39例作对照,检测3组的血清AFP、AFU、CA19-9水平,并对其进行比较。结果原发性肝癌(PHC)组AFP、AFU、CA19-9水平明显高于肝硬化组和健康组;原发性肝癌(PHC)组的联合检测阳性率为91.2%,明显高于肝硬化组的43.8%及健康组的2.6%,差异有统计学意义(P<0.05)。结论患者血清AFP、AFU、CA19-9的联合检测可提高PHC诊断率,对早期原发性肝癌诊断、治疗具有重要的临床意义。更多还原

【Abstract】 Objective To investigate the value of joint detection of serum alpha fetoprotein(AFP),alpha- L- fucusglycosidase(AFU),carbohydrate antigen(CA19-9)in diagnosis of primary hepatocellular carcinoma(PHC). Methods The34 blood samples collected from hospitalized patients with PHC from June 2011 to June 2012 were as PHC group, 32 withhepatocirrhosis as cirrhosis group,and 39 healthy persons during the same period in the hospital as healthy group. The levels ofserum AFP, AFU and CA19-9 in all samples of three groups were detected and compared. Results The levels of AFP, AFU,CA19-9 in cases of PHC-group were obviously higher than that of cirrhosis group and healthy group. The positive rate of jointdetection of AFP, AFU, CA19-9 in PHC-group was 91.2%, significantly higher than the 43.8% in cirrhosis-group and the2.6% in healthy-group. And the difference was statistically significant(P<0.05).Conclusion The joint detection of serumAFP, AFU, CA19-9 can improve the rate in diagnosis of PHC with fundamentally clinical significance for early diagnosis andtreatment of primary hepatocellular carcinoma.更多还原