【摘要】 目的探讨老年支气管哮喘患者急性发作期外周血白细胞介素4(IL-4)和血白细胞介素18(IL-18)水平及其临床意义。方法 2012年7月至2014年10月,急性发作期老年哮喘患者82例(哮喘组),男54例,女28例,年龄60~83岁,平均(71.5±8.08)岁;对所有患者入院急性发作期和治疗后缓解的人血清中IL-4、IL-18水平采用ELISA法检测。结果急性发作期老年哮喘患者的血清IL-4明显高于缓解期(P<0.05),IL-18明显高于缓解期(P<0.05)。结论 IL-4、IL-18均参与了老年支气管哮喘急性发作期的发病机制,在Th1/Th2细胞因子网络失衡的发病机制中起重要的调节作用。更多还原

【Abstract】 Objective We aimed to investigate the clinical significance of the level of interleukin- 4( IL- 4) and interleukin- 18( IL- 18) in the acute phase of elder patients with asthma. Methods 82 elder patients who suffered from asthma in the acute phase were enrolled in this study,54 male and 28 female,they aged from60 to 83 years old,71. 5 ± 8. 08 years old on average. These patients were hospitalized in our hospital during July2012 and November 2014. The level of IL- 4 and IL- 18 were detected by Enzyme- linked immunosorbent assay( ELISA). Results The concentration of IL- 4 and IL- 8 in the acute phase was significantly higher than that in the remission phase( P < 0. 05). Conclusions The levels of IL- 4 and IL- 8 play an important role in allergic reaction in the acute phase of elder patients with asthma.更多还原