【摘要】 目的检测实体瘤患者血清骨碱性磷酸酶(s BALP)水平,评价实体瘤骨转移早期的临床诊断价值。方法选择2009年1月至2012年12月经龙华人民医院确诊的实体瘤患者38例。采用化学发光法定期测定患者血清中s BALP、CA125、CA153、CEA的水平。结果实体瘤骨转移患者早期血清s BALP、CA125、CA153、CEA水平明显高于未转移患者s BALP、CA125、CA153、CEA水平,其浓度与骨转移负荷成正相关。结论骨代谢标记物s BALP在恶性肿瘤骨转移早期的诊断;对治疗反应的监测及骨相关事件的预测方面具有一定的价值。更多还原

【Abstract】 Objective In this article we detected the concentration of serum bone alkaline phosphatase( s BALP) of solid tumor patients,aimed to evaluate the clinical value of early diagnosis of metastatic bone tumor.Methods 38 patients with solid tumors during January 2009 and December 2012 and diagnosed in Longhua people’s hospital were enrolled in this study. The concentration of s BALP,CA125,CA153 and CEA in serum were measured by chemiluminescence method regularly. Results The levels of s BALP,CA125,CA153 and CEA in bone metastases patients were significantly higher than those without metastasis,its concentration was related to bone metastasis load. Conclusions s BALP,the bone metabolic marker,has certain value in early diagnosis of metastasis of malignant tumor to bone,as well as predicting and monitoring of skeletal- related events in response to treatment.更多还原