【摘要】 目的探讨宜昌地区健康体检女性26种人乳头瘤病毒(human papillomavirus,HPV)的感染状况,并分析HPV不同亚型感染与不同宫颈病变的对应关系,同时为该地区HPV亚型的流行病学特点提供理论依据。方法选择2014-08-01-2014-10-13宜昌市中心人民医院1 008例23~78岁健康体检女性,采集宫颈脱落细胞,通过基因芯片技术分析17种高危型和9种低危型HPV亚型的分布,同时配对进行液基细胞学检查。结果 1 008例妇女中,HPV阳性者232例(23.00%),总感染型为313例。26种HPV亚型感染率前5位的分别是HPV16为14.06%(44/313),HPV58为12.46%(39/313),HPV52为9.27%(29/313),HPV54为7.35%(23/313),HPV51为6.71%(21/313)。>30~35岁年龄段女性的HPV检出率为37.6%(44/117),与≤30岁(χ2=7.770,P=0.005)、>35~40岁(χ2=7.682,P=0.006)、>40~45岁(χ2=14.909,P<0.001)、>45~50岁(χ2=7.996,P=0.005)和>50岁(χ2=8.875,P=0.003)比较,差异均有统计学意义;高危HPV感染率为31.6%(37/117),与≤30岁(χ2=4.544,P=0.033)、>35~40岁(χ2=8.857,P=0.003)、>40~45岁(χ2=11.976,P=0.001)、>45~50岁(χ2=5.843,P=0.016)和>50岁(χ2=7.504,P=0.006)比较,差异均有统计学意义;其中>30~35岁年龄段女性的HPV检出率为37.6%(44/117),高危HPV感染率为31.6%(37/117),均最高,与其他不同年龄段人群分别比较,差异均有统计学意义,P<0.05,符合流行病学特征。液基细胞学结果显示,HPV感染与宫颈上皮内病变密切相关。结论高危型HPV16、58和52型作为宜昌地区的优势型别,应纳入HPV疫苗研究重点。>30~35岁妇女应列入宫颈癌前病变或子宫颈癌的重点筛查对象。更多还原

【Abstract】 OBJECTIVE To explore the distribution of 26 subtypes of human papillomavirus(HPV)infection among women at physical examination from Yichang area in the Hubei Province,and analyze the relationship between the HPV infection and different cervical lesions.The epidemiologic features of HPV genetypes infection were also analyzed.METHODS Totally 17high-risk and 9low-risk HPV genotype were detected by gene chips technology,and liquid based cytology was analyzed at 1 008 cases of 23-78 years old healthy females,which were from August to October of 2014 at the Yichang Central People’s Hospital.RESULTS In 1 008 cases of women,positive rates of HPV infection were23.00%,the total infection type was 313 cases.The top five subtypes in the 26 subtypes of HPV infection were HPV16(14.06%,44/313),HPV58(12.46%,39/313),HPV52(9.27%,29/313),HPV54(7.35%,23/313)and HPV51(6.71%,21/313).HPV infection rates(37.6%,44/117)in the 31-35 years of the female were both the highest,compared with other different age groups,≤30years(χ2=7.770,P=0.005),>35-40years(χ2=7.682,P=0.006),>40-45years(χ2=14.909,P<0.001),>45-50years(χ2=7.996,P=0.005),>50years(χ2=7.504,P=0.006),there were significant differences.The high risk HPV infection rates(31.6%,37/117)in the>30-35 years group was obviously higher than others and had significant differences,≤30years(χ2=4.544,P=0.033),>35-40years(χ2=8.857,P=0.003),>40-45years(χ2=11.976,P=0.001),>45-50years(χ2=5.843,P=0.016),>50years(χ2=7.504,P=0.006).These there were significant differences(P<0.05),these results were in concordance with the epidemiological characteristics.Liquid based cytology results showed that cervical intraepithelial lesions were closely related with HPV infection.CONCLUSIONS High risk type of HPV16,HPV58 and HPV52as the area specialized subtypes,should be regarded as the HPV vaccine research focus.31-35 years old females should be included in the screening object of cervical precancerous lesions or cervical cancer.更多还原