【摘要】 目的分析男性乳腺癌(male breast cancer,MBC)患者临床病理特征及其预后影响因素。方法回顾性分析2001-07-01-2012-07-31诊治于郑州大学附属肿瘤医院的49例MBC患者的临床病理特征及生存情况。应用KaplanMeier法进行生存率估计,Log-rank检验进行组间生存率比较,Cox比例风险回归模型进行预后因素的分析。结果单因素分析结果显示,肿瘤大小(P=0.033)、腋窝淋巴结状态(P<0.001)、雌激素受体(estrogen receptor,ER)状态(P=0.002)、放疗(P=0.005)以及内分泌治疗(P=0.008)是影响MBC患者无病生存率的预后因素。肿瘤大小(P=0.035)、临床TNM分期(P=0.037)、腋窝淋巴结状态(P=0.001)、内分泌治疗(P=0.003)及局部复发或远处转移(P<0.001)是影响MBC患者总生存率的预后因素。多因素分析结果表明,ER状态(HR=0.138,95%CI:0.131~0.651,P=0.012)、腋窝淋巴结状态(HR=20.897,95%CI:2.303~189.625,P=0.007)是影响MBC患者无病生存率的预后因素。内分泌治疗(HR=0.166,95%CI:0.033~0.820,P=0.028)是影响MBC患者总生存率的预后因素。结论 MBC发病率低,预后差,内分泌治疗可能是影响MBC患者预后的重要因素之一。更多还原

【Abstract】 OBJECTIVE To analyze the clinical characteristics and explore the prognostic factors affecting male breast cancer(MBC).METHODS A retrospective method was adopted in this study to analyze the clinicopathologic features and survival conditions of 49 cases of MBC patients,who were diagnosed and treated in the Affiliated Tumor Hospital of Zhengzhou University from July 1,2001 to July 31,2012.The Kaplan-Meier method was employed to estimate the survival rate,the Log-rank test was adopted to compare the survivals between two groups,and the Cox regression model was used to analyze the prognostic factors.RESULTS Univariate analysis showed that the tumor size(P=0.033),axillary lymph node status(P<0.001),estrogen receptor status(P=0.002),radiotherapy(P=0.005)and endocrine therapy(P=0.008)were factors significantly influencing the prognostic of disease-free survival.Univariate analysis showed that the tumor size(P=0.035),TNM stage(P=0.037),axillary lymph node status(P=0.001),endocrine therapy(P=0.003)and recurrence or metastasis(P<0.001)were prognostic factors significantly influencing the overall survival.Multivariate Cox regression showed that the axillary lymph node status(HR=0.138,95%CI:0.131-0.651,P=0.012)and the estrogen receptor status(HR=20.897,95%CI:2.303-189.625,P=0.007)were factors affecting the prognostic of disease-free survival for MBC;the endocrine therapy(HR=0.166,95%CI:0.033-0.820,P=0.028)was the prognostic factor influencing the overall survival for MBC.CONCLUSIONS Male breast cancer has a low incidence rate and poor prognosis.Endocrine therapy seemed to be one of the important factors affecting the prognosis of patients suffering from MBC.更多还原