【摘要】 目的了解湖北省某院抗癫痫药物(AEDs)的利用情况及发展趋势。方法对2010—2013年十堰市太和医院AEDs的用药品种、销售金额、用药频度(DDDs)、日均费用(DDC)、年均增长率(AARG)及排序比值(RM)进行统计分析。结果该院传统AEDs有6个品种,分别为苯妥英钠、卡马西平、丙戊酸钠、苯巴比妥,其中丙戊酸钠有国产的普通片剂和国内外合资的缓释片剂,卡马西平有国产的普通片剂和国内外合资的片剂;新型AEDs有5个品种,分别为左乙拉西坦、拉莫三嗪、奥卡西平、托吡酯和加巴喷丁。2010—2013年AEDs的销售金额和DDDs逐年增长,AARG为13.85%,丙戊酸钠缓释片、丙戊酸钠和奥卡西平4年中DDDs排序始终保持在前3位;新型AEDs的DDC(16.93~36.28)明显高于传统AEDs(0.38~5.22),且RM均大于1。结论经济因素影响着AEDs的选择,该院AEDs仍以传统AEDs为主,需大力发展新型AEDs的自主研发,切实降低药价,造福广大患者。更多还原

【Abstract】 Objective To investigate the application status and development trend of antiepileptic drugs( AEDs) in a hospital in Hubei. Methods Statistical analyses were conducted on the 2010—2013 data of AEDs in Taihe Hospital in Shiyan. The data included drug varieties, sales amount, defined daily doses( DDDs), defined daily cost( DDC), annual average rate of growth( AARG) and sorting ratio( RM). Results There were 6 major varieties of traditional AEDs,including dilantin, carbamazepine, sodium valproate and phenobarbital. The sodium valproate had two subcategories, the common homemade tablets and controlled- release tablets jointly made by home and abroad companies. The carbamazepine also had two subcategories,the common homemade tablets and tablets jointly made by home and abroad companies. New AEDs had 5 varieties including levetiracetam,lamotrigine,oxcarbazepine,topiramate and gabapentin. Between 2010 and 2013,the sales amount and DDDs of AEDs increased year by year with an AARG of 13. 85%; controlled- release tablets of sodium valproate, sodium valproate and oxcarbazepine remained the top three in the four years. New AEDs( 16. 93- 36. 28) were distinctly higher than traditional AEDs( 0. 38- 5. 22) in DDC,and both of them had RM higher than 1. Conclusion Economic factors affect the choice of AEDs. The traditional AEDs are still the primary choice for treatment. The independent research and development of new AEDs should be strengthened and promoted in order to reduce the drug price and bring benefit to patients.更多还原