【摘要】 目的研究丹红注射液治疗缺血性脑卒中患者的临床效果及其对患者血脂代谢和神经功能的影响。方法入选2012年6月至2014年6月在江苏省常州市第三人民医院就诊的缺血性卒中患者90例,随机分为对照组和观察组,每组各45例。对照组患者给予常规治疗(吸氧、降血压、抗血小板、抗感染等西药治疗),观察组在对照组治疗基础上加用丹红注射液静脉滴注,均连续治疗28 d,比较两组患者临床治疗效果、血脂代谢及神经功能缺损程度评分(NFDS)改善情况。结果经治疗后,观察组患者总有效率为93.3%,明显高于对照组患者(77.8%),差异具有统计学意义(P<0.05);治疗后两组患者血脂指标总胆固醇、三酰甘油、低密度脂蛋白胆固醇及NDFS评分明显降低,高密度脂蛋白胆固醇水平明显升高,且观察组改善更显著,两组比较差异均有统计学意义(P<0.05)。结论丹红注射液治疗缺血性脑卒中患者具有确切的临床治疗效果,且可以显著改善患者的血脂代谢水平,提高患者的神经功能,值得临床上进一步研究应用。更多还原

【Abstract】 Objective To study the clinical efficacy of Danhong Injection on cerebral ischemic stroke and its influence on blood lipid metabolism and nerve function. Methods The patients with cerebral ischemic stroke(n=90) were chosen from Jun. 2012 to Jun. 2014, and randomly divided into control group and observation group(each n=45). The control group was given routine therapy(oxygen uptaking, anti-hypertension, anti-platelet, antiinfection), and observation group was given additionally intravenous drip of Danhong Injection for 28 d continuously. The clinical efficacy, lipid metabolism and neurological functional deficit score(NFDS) were compared in 2 groups. Results The total effective rate was 93.3% in observation group and 77.8% in control group(P<0.05). The levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein-cholesterol(LDL-C) and NFDS decreased significantly in 2 groups, which was more significant in observation group(P<0.05). Conclusion Danhong Injection has reliable clinical efficacy in patients with cerebral ischemic stroke, and can improve significantly blood lipid metabolism and nerve function, which is worth to be popularized and applied in clinic.更多还原