【摘要】 目的探讨大剂量甲基强的松龙冲击疗法治疗多发性硬化的临床疗效。方法选取2008年3月-2010年6月医院收治的多发性硬化者76例,随机分为大剂量甲基强的松龙冲击疗法组(试验组)和地塞米松治疗组(对照组)各38例。给予2组患者相应药物治疗,比较2组治疗效果、EDSS评分、平均治疗时间和生活质量评分以及复发情况。结果试验组总有效率为78.95%明显高于对照组的57.89%,差异有统计学意义(P<0.05)。治疗结束时试验组EDSS评分较对照组低、平均治疗时间较对照组缩短,差异有统计学意义(P<0.05)。试验组复发率明显低于对照组,差异有统计学意义(P<0.05)。结论大剂量甲基强的松龙冲击疗法治疗多发性硬化效果显著且安全可靠,值得临床推广、研究。更多还原

【Abstract】 Objective To observe the clinical effect of high-dose methylprednisolone pulse therapy in the treatment of multiple sclerosis. Methods From March 2008 to June 2010,76 cases of patients with multiple sclerosis were selected and divided into high-dose methylprednisolone pulse therapy group( experimental group) and dexamethasone treatment group( control group) with reference to the random number table,each of 38 cases. Both groups were given the corresponding drug treatment. The treatment effect,EDSS scores,the average duration of treatment and life quality score,and recurrence of the 2 groups were observed. Results The total effect rate of the treatment group was up to 78. 95%,which was higher than 57. 89% of the control group,the difference was statistically significant( P < 0. 05). The EDSS scale improvement was better than the control group; the average treatment time was significantly shorter than the control group,the differences were statistically significant( P < 0. 05). The recurrence rate of the experimental group is lower than the control group,the difference was statistically significant( P < 0. 05). Conclusion The effect of high-dose methylprednisolone pulse therapy in the treatment of multiple sclerosis is significant and the role of which is reliable,which is worthy of clinical promotion and further research.更多还原