【摘要】 卵泡刺激素(FSH)是一种由脑垂体合成并分泌的激素,与支持细胞膜上的FSH受体(FSHR)结合,提高支持细胞合成雄激素结合蛋白的水平,同时分泌抑制素,在生精过程中起到至关重要的作用。随着DNA测序技术的发展,检测到FSH基因单核苷酸多态性(SNP)rs10835638和FSHR基因SNPs rs6165,rs6166,rs1394205,这些SNPs可能直接影响FSH表达水平和FSHR的活性,在男性主要表现为精子发生障碍。本文综述FSH及FSHR基因多态性与男性精子发生的相关性。更多还原

【Abstract】 Follicle-stimulating hormone( FSH) is synthesized and secreted by the anterior pituitary,which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis. With the development of DNA sequencing technology,FSH SNPs rs10835638 and FSHR SNPs rs6165,rs6166,and rs1394205 were detected,which might directly affect the expression of FSH and activity of FSHR,resulting in male spermatogenic dysfunction. This review focuses on the relationship of FSH and FSHR gene polymorphisms with male infertility.更多还原