【摘要】 目的:比较盐酸达泊西汀及舍曲林治疗早泄患者的疗效及不良反应。方法:门诊就诊的早泄患者按2∶1比例随机分配接受盐酸达泊西汀(30 mg,按需服用,n=78)或舍曲林(50 mg,每日1次,n=39)治疗,4周后随访,记录用药前后的阴道内射精潜伏时间(IELT),用药后临床总体印象变化(CGIC)评分,并记录不良反应。结果:经治疗后盐酸达泊西汀组及舍曲林组IELT均显著增加[盐酸达泊西汀:(0.87±0.31)min延长至(2.84±0.86)min;舍曲林:(0.84±0.28)min延长至(2.71±0.92)min]。应用CGIC评分,用药后效果很好或好的比率分别为36.5%及37.5%(盐酸达泊西汀vs舍曲林);CGIC评价有效(很好、好、稍好)的比率分别为63.5%和71.9%。舍曲林组头晕、恶心、头痛及腹泻的发生率稍高于盐酸达泊西汀组但差异不具显著性,但舍曲林组疲劳、嗜睡以及口干的发生率显著高于盐酸达泊西汀组(P<0.05)。结论:按需口服盐酸达泊西汀治疗早泄患者安全有效。更多还原

【Abstract】 Objective:To investigate the efficacy and adverse effects of dapoxetine in the treatment of premature ejaculation.Methods:We randomly assigned outpatients with premature ejaculation in the proportion of 2∶ 1 to receive 30 mg dapoxetine on demand(n = 78)or 50 mg sertraline qd for one month(n = 39).Follow-up was accomplished in 95 cases,63 in the dapoxetine group and 32 in the sertraline group.We recorded the intravaginal ejaculatory latency time(IELT),clinical global impression of change(CGIC)score,and adverse reactions of the patients and compared them between the two groups.Results:IELT was significantly increased in both the dapoxetine(from [0.87 ± 0.31]to [2.84 ± 0.68]min,P < 0.05)and the sertraline group(from [0.84 ± 0.28]to [2.71± 0.92] min,P < 0.05)after medication.Based on the CGIC scores in premature ejaculation,the rate of excellence or effectiveness was 36.5% in the dapoxetine and 37.5% in the sertraline group,and the rate of improvement was 63.5% in the former and 71.9%in the latter.The incidence rates of dizziness,nausea,headache,and diarrhea were slightly higher(P > 0.05)while those of fatigue,somnolence,and dry mouth significantly higher(P < 0.05)in the sertraline than in the dapoxetine group.Conclusion:On-demand oral medication of dapoxetine is effective and well-tolerated for the treatment of premature ejaculation.Natl J Androl,2015,21(10):892-895更多还原