【摘要】 目的 :了解江苏省某地区既往有偿献血人员丙型肝炎病毒(hepatits C virus,HCV)的感染情况并探讨其危险因素。方法:对该地区部分有既往有偿献血史的村民进行问卷调查和肝脏B超检查,并采集静脉血进行相关生化检测。应用Epi Data和SPSS软件对数据进行录入及统计学分析。结果:781名调查对象共检测出抗-HCV抗体阳性510例,感染率为65.3%,抗体阳性者中持续感染者占70.6%(360/510),自限清除者占29.4%(150/510)。HCV持续感染者以1b+3混合型(51.7%)和1b型(32.9%)为主。持续感染组丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、谷氨酰转移酶(GGT)的异常率高于未感染组和自限清除组。多因素Logistic回归分析显示性别、献全血史和单采血浆史是既往有偿献血人群感染HCV的危险因素,OR值分别为1.50、2.27和3.27;年龄是HCV感染慢性化的危险因素,OR值为1.62。结论 :既往有偿献血人群的HCV感染率处于较高水平,不洁采供血特别是单采血浆可能是导致HCV高感染率的主要原因。更多还原

【Abstract】 Objective:To investigate the prevalence of HCV infection and risk factors among paid blood donors in rural area of Jiangsu Province. Methods:Questionnaires and ultrasound examination were administered,and 5 m L blood sample of each subject was collected to detect HCV anti-body,HCV-RNA,and other biochemical indicators. Epi Data and SPSS were used for statistical analysis of risk factors. Results:The prevalence of HCV infection among these paid blood donors was 65.3%(510/781),including70.6%(360/510) of chronic infection and 29.4%(150/510) of spontaneous clearance. The dominant genotypes of HCV are 1b and1b+3 mixed. The abnormal rate of ALT,AST,and GGT are highest in the group of chronic infection. Multivariate logistic regression analysis indicated that sex,history of donating blood,and history of donating plasma were the risk factors of HCV infection(OR=1.50、2.27,and 3.27,respectively). Age was a risk factor for chronicity of HCV infection with OR of 1.62. Conclusion:The prevalence of HCV infection among the paid blood donors was higher than that of general population due to illegal blood donation,especially donating plasma.更多还原