【摘要】 目的对新橙皮苷二氢查尔酮(NHDC)的美白性能进行分析,探讨其作为美白产品添加剂的可能性。方法以β-熊果苷、VC、以及曲酸这3种常用美白剂为对照,体外氧化多巴反应法观察NHDC对酪氨酸酶的抑制活性,NaOH裂解法测定其对B16小鼠黑色素瘤细胞黑色素合成能力的抑制作用。进而以NHDC为主要有效成分制备面膜液,测定各种指标并进行人体安全性测试。结果与β-熊果苷、VC、和曲酸相比,NHDC的酪氨酸酶抑制率最高。NHDC对生成的抑制能力与VC和曲酸接近,为β-熊果苷的3倍。以NHDC为主要有效成分所制成的面膜液,可通过人体安全性测试。结论与β-熊果苷,VC,和曲酸等常用美白活性物质相比,NHDC具有更为卓越的综合性能,是一种具有应用潜力的新型美白剂,可作为主要活性成分用于新型美白护肤品的开发中。更多还原

【Abstract】 Object To investigate the performance of neohesperidin dihydrochalcone( NHDC) in whitening,and discuss the possibility of NHDC as the main effective components in whitening products.Method With three commonly used whitening agents for the control,including β-arbutin,kojic acid,and VC,the tyrosinase inhibitory activity of NHDC in vitro was measured by the rate of oxidation of LDopa,and the inhibitory effect to melanin synthesis in mouse melanoma cell lines B16 was measured by NaOH lysis method. At the same time,mask liquid was compounded using NHDC as the main effective ingredients,various indicators were determined,and human safety tests were made. Result Comparing with β-arbutin,kojic acid,and VC,NHDC had the highest tyrosinase inhibitory activity.The inhibitory effect to melanin synthesis of NHDC was 3 times than β-arbutin,similar to kojic acid and VC. The mask liquid with NHDC as the main effective components was safety to human body.Conclusion Comparing with these three commonly used whitening agents,NHDC has more excellent comprehensive performance,is a new type whitening agent having the potential applications of,and could be used in the development of new type of whitening cosmetics.更多还原