【摘要】 目的观察急性脑梗死患者阿司匹林抵抗发生情况及影响急性脑梗死患者阿司匹林抵抗的相关因素。方法 2010年10月-2011年11月在我院神经内科住院治疗的176例急性脑梗死患者作为研究对象,根据入院前是否服用阿司匹林分为两组:已服组32例,未服组144例。入院后两组均服拜阿司匹林100mg·d-1,连服1w后用全血电阻法监测两组阿司匹林抵抗发生情况,,分为阿司匹林抵抗组和阿司匹林敏感组,分析两组在性别、年龄、血常规、生化指标、心电图、超声心动图、颈动脉彩超及基础疾病等方面的差异。结果 176例脑梗死患者中发生阿司匹林抵抗27例,发生率为15.3%,发生阿司匹林半抵抗97例,发生率为55.1%。阿司匹林抵抗发生情况与入院前是否服用阿司匹林无明显关系(P>0.05)。阿司匹林抵抗组在性别、血小板计数、白细胞计数、糖化血红蛋白与阿司匹林敏感组比较差异有统计学意义(P<0.05)。结论服用阿司匹林的急性脑梗死患者阿司匹林抵抗是完全存在的。发生阿司匹林抵抗可能与性别、血小板数、白细胞数及糖化血红蛋白等因素有关。更多还原

【Abstract】 Objective To investigate the prevalence of aspirin resistance in the patients with acute cerebral infarction and the correlative factors of aspirin resistance in the patients with acute cerebral infarction who had taken aspirin regularly. Methods All of 176 patients with acute cerebral infarction were from the Department of Neurology,Suzhou Municipal Hospital during from October 2010 to November 2011. According to they had been admitted to hospital whether or not oral aspirin divided into two groups: had medicated 31 cases,unmedicated 145 cases. All patients in the groups taken aspirin regularly( 100mg·d-1) for a week,then observed the prevalence of aspirin resistance in two groups. Analysed the results of the index of blood test,sex,clinical disease and so on between aspirin resistance and aspirin sensitive in the patients. Results There were 27 cases with aspirin resistance in 176 patients of acute cerebral infarction,the incidence was 15.3% and 97 cases with aspirin semi-resistance in 176 patients of acute cerebral infarction,the incidence was 55.1%. The incidence rate of aspirin resistance in the patients with acute cerebral infarction has no obvious relationship to whether or not oral aspirin before they had been admitted to hospital. Aspirin resistant were most likely to be women,the platelet count,white blood cell count and glycosylated hemoglobin levels of aspirin resistance were on the high side compared with aspirin sensitive. The difference was remarkable( P<0.05). Conclusion Aspirin resistance really existed in the patients with acute cerebral infarction who had taken aspirin regularily. The event of aspirin resistance and aspirin semi-resistance are likely correlated with sex,platelets,white blood cells and glycosylated hemoglobin.更多还原