【摘要】 目的:评价深部热疗联合顺铂同期放化疗治疗局部晚期宫颈癌疗效及毒性反应。方法:IIb-IIIb期病理确诊宫颈癌初治患者被分为两组。研究组采用顺铂同步放化疗+热疗,对照组采用顺铂同步放化疗。比较两组患者的近期疗效、局控率、生存率及毒性反应。结果:研究组的有效率为100%,对照组有效率为85.7%。研究组2年局控率和生存率分别为100%和95.3%,对照组2年局控率和总生存率是92.2%和100%。研究组2年局控率高于对照组(P<0.05)。两组患者急性和晚期毒性反应比较差异没有统计学意义(P>0.05)。结论:热疗联合同期放化疗能提高局部晚期宫颈癌的局控率,有较好的耐受性,没有明显增加毒性反应,还需要增加样本量及延长随访时间验证其临床价值。更多还原

【Abstract】 Objective: To investigate the curative effect of hyperthermia combined with cisplatin concurrent radiochemotherapy in locally advanced cervical cancer. Methods: The initially-treated patients with histologically confirmed cervical cancer(stage IIb-IIIb) were randomly assigned to research group carried out hyperthermia combined with cisplatin concurrent radiochemotherapy, and control group, only received cisplatin concurrent radiochemotherapy. The short-term clinical efficacy,local control rate, overall survival rate and toxic reactions were compared between the two groups. Results: The effective rates of research group and control group were100% and 85.7 %, repectively. The 2-year local control rate and overall survival rate were 100% and 95.3% in research group and 92.2 % and 100 % in control group. The 2-years local control rate of research group was significantly higher than that of the control group(P < 0.05). There was statistically significant difference in acute and late adverse reactions between two groups(P > 0.05). Conclusion: Hyperthermia combined with radiochemotherapy can improve the local control rate of locally advanced cervical cancer patients. It is well-tolerated and does not significantly increase the toxicity. The sample size and the follow-up time need increasing to verify its clinical value.更多还原