【摘要】 目的:分析2011~2013年宜宾地区下呼吸道感染铜绿假单胞菌率的变迁及耐药趋势,指导该地区医务人员合理应用抗菌药物治疗铜绿假单胞菌所致的下呼吸道感染。方法:分析获自宜宾市第一、二人民医院2011年至2013年下呼吸道标本分离出的726株铜绿假单胞菌,比较铜绿假单胞菌感染率的变化趋势,及铜绿假单胞菌12种抗菌药耐药趋势。结果:2011~2013年下呼吸道感染标本中分离出铜绿假单胞菌分别为5.33%、4.86%、2.43%(P<0.05);药敏结果显示铜绿假单胞菌对β-内酰胺类、喹诺酮类和磺胺类耐药率较高(>21%),对亚胺培南、哌拉西林他唑巴坦、氨基糖苷类耐药率较低(<20%)。结论:铜绿假单胞菌所致的下呼吸道感染较少;宜宾地区可经验性选择抗菌药物亚胺培南、哌拉西林他唑巴坦、氨基糖苷类治疗可疑铜绿假单胞菌感染。更多还原

【Abstract】 Objective: To Analyze the change of infections rate and drug resistance of Pseudomonas aeruginosa in lower respiratory tract infections in Yibin region from 2011 to 2013 in order to guide the rational use of antimicrobial drugs. Methods: 726 strains of Pseudomonas aeruginosa isolated from lower respiratory tract specimens from the first and second People’s Hospitals of Yibin city from 2011 to 2013 were abalyzed, then the infections rate and 12 kinds of antimicrobial drug resistance trends in the 3 years were compared. Results: The isolation rate of Pseudomonas aeruginosa in 2011, and 2013 were 5.33%, 4.86% and 2.43% respectively(P <0.05), susceptibility of Pseudomonas aeruginosa to β- lactams, quinolones and sulfa drugs were higher(> 21%).While to Imipenem, piperacillin-tazobactam and aminoglycosides were lower(< 20%). Conclusion: The lower respiratory tract infection caused by Pseudomonas aeruginosa is less common in Yibin region, The treatment of suspected Pseudomonas aeruginosa infection in this region can empirically select the antibiotics of imipenem,Piperacillin-tazobactam and aminoglycoside.更多还原