【摘要】 目的:探讨软骨母细胞瘤的临床、影像学、病理形态学和免疫组化特征,明确病理诊断及鉴别诊断。方法:收集我院1998年至2014年经病理证实的20例软骨母细胞瘤,用HE和免疫组化方法进行病理学观察,同时分析其临床和影像学特点。结果:20例患者中男性13例,女性7例,多发于青少年,平均年龄17岁,>20岁者4例。最常见的部位是长骨(75%),尤其是股骨、胫骨和肱骨,其他部位5例。X线通常表现为骨骺或骨突部位圆形或卵圆形地图状溶骨性骨质破坏,边界清楚,常有薄层边缘硬化,破坏区常见细小的斑点状钙化或骨化阴影,很少膨胀性改变和骨膜反应。1例有局部骨皮质破坏合并动脉瘤样骨囊肿。镜下软骨母细胞瘤由增生的软骨母细胞、粉红色软骨样基质及散在破骨样巨细胞组成,"窗格样钙化"和免疫组化软骨母细胞S-100(+)对正确诊断十分重要。结论:掌握软骨母细胞瘤的临床、影像学、病理形态和免疫组化特征,对软骨母细胞瘤的病理诊断及鉴别诊断具有重要意义。更多还原

【Abstract】 Objective: To study the clinical, patho morphologic, radiographic and immunohistochemical characteristics of chondroblastoma for pathological diagnosis and antidiastole. Methods: 20 patients with chondroblastoma from 1998 to 2014 were retrospectively reviewed. Hematoxylin eosin(HE) staining and immunohistochemical(IHC) staining were applied. Radiographic and clinical were characteristics were reviewed.Results: The disease occurred predominantly in adolescents(mean age 17, 4 cases > 20), more common in males(13 men and 7 women). The common location was long bone, particularly tibia, femur and humerus, only 5 cases occurred in other bones. X- ray showed circular or ovoid, expanded, lytic lesion in the epiphysis of bone, often containing irregular calcifications, mostly without periosteal reaction. The lesion usually had a thin sclerotic border. Chondroblastoma with aneurysmal bone cyst occurred in one case. Microscopically, the characteristic findings was abundance of immature eosinophilical chondroid matrixes, hypercellularity of the chondroblasts, and "chicken-wire-like" calcifications. Immunohistochemically, the positive expression of S-100 protein was helpful for correct diagnosis. Conclusions: Understanding of the characteristics of clinicpathology, radiographs, and immunohistochemical markers on chondroblastoma is essential for diagnosis and differential diagnosis of chondroblastoma.更多还原